Merck targets BMS' stomach cancer head start with Keytruda win ... - FiercePharma
[unable to retrieve full-text content] Merck targets BMS' stomach cancer head start with Keytruda win ... FiercePharma
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Effect of pharmacogenetic variations on praziquantel plasma ... - Nature.com
Abstract School-based mass drug administration (MDA) of Praziquantel (PZQ) is the global intervention strategy for elimination of schistosomiasis. Genetic variations in drug metabolizing enzymes and transporter proteins influences drug exposure and treatment outcomes, but data on PZQ pharmacokinetics and safety outcomes are scarce. We investigated the effect of pharmacogenetics variations on PZQ plasma concentrations and safety outcomes among 462 Rwandan schoolchildren who received single dose PZQ and albendazole in MDA. Genotyping for common functional variant alleles CYP3A4*1B , CYP3A5 (*3, *6, *7), CYP2C19 (*2, *3, *17), CYP2C9 (*2, *3) and CYP2J2*7 were done. Plasma concentration of PZQ, cis -4-OH-PZQ and trans -4-OH-PZQ were measured using LC/MS/MS. Active safety monitoring was done on days 1, 2, and 7 post-MDA. CYP2C9 and CYP2C19 genotypes were significantly associated with PZQ plasma concentrations and its cis - and trans -4-OH-PZQ/PZQ metabolic ratios (MR). CYP2C9*2 and ...
Blue toe syndrome: Causes, treatment, outlook, and prevention - Medical News Today
When one or more of a person's toes starts to look blue or purple, doctors call it blue toe syndrome. There are several triggers, most of which relate to the circulatory system. This article explains what blue toe syndrome is, what it feels like, its causes, and how doctors treat it. It will also explore the possible complications of blue toe syndrome and when to see a doctor. Share on Pinterest Blue toe syndrome can cause muscle pain in the legs, as well as severe pain in the foot. Doctors sometimes call it occlusive vasculopathy or trash foot. Blue toe syndrome is a form of acute digital ischemia. This means it occurs when the toes do not get enough blood. A person's blood carries oxygen from the lungs to every part of their body. Each cell needs oxygen to repair itself and multiply. The blood also brings cells all the nutrients they need and carries away waste products. Not getting enough blood damages cells and the tissues they make up. This can cause the tissue to change c...
MVHS launches new OBGYN Residency Program | News | wktv.com - WKTV
UTICA, N.Y. -- Mohawk Valley Health System has launched a new four-year, Obstetrics and Gynecology (OB/GYN) Residency Program. The program has been granted accreditation status for 16 residents in total, or four per year, with the first four residents to begin on July 1. "Our new OB/GYN residency training program will have a tremendous positive effect on the Mohawk Valley region. This academic program, along with our well-rounded OB/GYN team, ensures that we will continue to deliver bab...
Community health workers fill care gaps among Bloomington ... - WGLT
Inconsistency is pretty much the only thing Coretta Jackson can count on. Jackson is a community health worker employed by Chestnut Health Systems, a job she's had a little over a year. Her role with Chestnut Health is supported by a grant called the Medicaid Innovation Collaborative, or MIC, for short. The five-year initiative is made possible through funding from the Illinois Department of Healthcare and Family Services. In 2021, Gov. JB Pritzker allocated $94.3 million for the Healthcare Transformation Collaboratives (MIC). Three million people in Illinois receive health insurance through Medicaid. MIC is one of 10 initiatives throughout the state aimed at increasing equitable access to quality health care. Central Illinois received $5 million of the money allocated to Medicaid Innovation. "The purpose is to bridge the health inequity gap," said Austin Howald, Chestnut's director of integrated community services. Several Chestnut programs fall under the MIC, includ...
Col. Ofelia Alvarez Willis, MD, is being recognized by Continental Who's Who - Yahoo Finance
SAN BERNARDINO, Calif. , Feb. 21, 2023 /PRNewswire/ -- Col. Ofelia Alvarez Willis , MD, is being recognized by Continental Who's Who as a Trusted Physician for her contributions to the Medical Field, Community Service, and Civic Service. Dr. Willis graduated Summa Cum Laude with a Bachelor of Arts in Biology and Chemistry and also a medical degree from the University of Montemorelos School of Medicine in Mexico in 1979 where she was class president. She completed a two-year residency in internal medicine with full compliment training at the Loma Linda University Health Education Consortium in 1983. She also completed an internship that involved general rotation of Internal Medicine Specialties from 1980 to 1981. The doctor spent one year at White Memorial Medical Center in Los Angeles, California completing a rotative internship/Fifth Pathway that included OB-GYN, Pediatrics, surgery, Psychology, and Emergency Room. The doctor is board certified in internal medicine, has more t...
Why collaboration is key to optimizing digital health - American Medical Association
Patients and physicians are navigating a fractured health care arena that spans across brick-and-mortar buildings and the virtual world that they embraced in 2020. As one AMA physician trustee put it, the state of digital health is comparable to the cartoon characters Fred Flintstone and George Jetson coexisting. That is, there have been tremendous strides in technologies that serve as tools in medicine, but physicians still find themselves having to fax a medical report to another office or perform 4,000 clicks a day, noted Meg Barron, the AMA's vice president of digital health strategy and innovations. "We are truly at an inflection point to how we navigate both existing and emerging models of care," she said during an AMA webinar. "Collaboration is absolutely going to be necessary. … None of this can happen in a vacuum. No one group can address this on its own. The overarching consensus is that we need to continue focusing on fixing the foundational issues—thi...